Lizzy Caplan (Mean Girls) and Michael Sheen (Midnight in Paris) have signed on as the leads in Masters of Sex.

Caplan and Sheen will portray human sexuality pioneers Virginia Johnson and William Masters in the Showtime drama pilot.

Masters of Sex chronicles the lives and the intriguing, unusual relationship between Masters and Johnson, the pioneers into the science of human sexuality, whose research touched off the sexual revolution.

Academy Award nominee John Madden (Shakespeare in Love) will direct, with Michelle Ashford, Judith Verno, and Sarah Timberman and Carl Beverly serving as executive producers.

Production is set to begin in New York later this year.

Source: Comingsoon