Summit Entertainment have released the first official trailer for upcoming cancer comedy 50/50.

Directed by Jonathan Levine (The Wackness), 50/50 stars Joseph Gordon-Levitt, Seth Rogen, Anna Kendrick, Bryce Dallas Howard, Anjelica Huston, Philip Baker Hall and Jessica Parker Kennedy.

A comedic account of a 27-year-old guy’s cancer diagnosis, and his subsequent struggle to beat the disease.

If this trailer is anything to go by, 50/50 is not only going to be funny, but also a sad and honest portrayal of a guy coming to terms with his cancer diagnosis.

50/50 will hit US cinemas on September 30.

Watch the trailer below: