After starring opposite Michelle Williams in Sarah Polley’s acclaimed Take This Waltz this summer, Seth Rogen returns to the big screen at the end of the year in Anne Fletcher’s The Guilt Trip.

We got the first look at Rogen and co-star Barbara Streisand last month, and now the first clip from the film has debuted over at Yahoo Movies.

“Andy Brewster is about to embark on the road trip of a lifetime, and who better to accompany him than his overbearing mother Joyce. After deciding to start his adventure with a quick visit at mom’s, Andy is guilted into bringing her along for the ride. Across 3,000 miles of ever-changing landscape, he is constantly aggravated by her antics, but over time he comes to realize that their lives have more in common than he originally thought. His mother?s advice might end up being exactly what he needs.”

Starring alongside Rogen and Streisand will be a pretty solid supporting cast, headed up by Adam Scott, Colin Hanks, Yvonne Strahovski, and Brett Cullen.

Fletcher (Step Up) is behind the camera for what promises to be an excellent comedy, directing from a script by Dan Fogelman, who penned Crazy, Stupid, Love., by far one of the best drama-comedies in recent years.

The Guilt Trip will be released in the US on Christmas Day, and will be going up against some strong competition in Les Misérables. Here in the UK, it will arrive on our shores on 22nd February, 2013, a slot still fairly empty. We’ve got a few months still to go, and hopefully there’ll be a trailer coming our way soon. For now, here’s the first clip. Enjoy.