Here’s our first look at Love and Other Drugs, Ed Zwick’s much-talked about romantic drama.

Love and Other Drugs stars Anne Hathaway, Jake Gyllenhaal, Oliver Platt, Judy Greer, Hank Azaria, Gabriel Macht and Josh Gad.

The script was co-written by Ed Zwick and Charles Randolph, and is based on Hard Sell: The Evolution of a Viagra Salesman.

Synopsis: Maggie (Hathaway) is an alluring free spirit who won’t let anyone – or anything – tie her down. But she meets her match in Jamie (Gyllenhaal), whose relentless and nearly infallible charm serve him well with the ladies and in the cutthroat world of pharmaceutical sales. Maggie and Jamie’s evolving relationship takes them both by surprise, as they find themselves under the influence of the ultimate drug: love.

Take a look at the official image below (via EW), and then the official trailer that follows.

Love and Other Drugs will hit cinemas in the US on September 24.