Milla Jovovich returns once more in Resident Evil: Retribution to the franchise she’s best known for, and with Paul W.S. Anderson back behind the camera and the script, I think we’re in for a lot of fun this September.

We got our first look at a short trailer for the film back in January, and now Yahoo Movies has debuted the first full-length trailer after Jovovich herself hosted a live webchat this afternoon.

“Alice is captured by Umbrella and awakens in the heart of their operation facility; as she moves further in the complex more of her past is unveiled and continues to hunt for those responsible for the outbreak. Her quest takes her and her newfound allies from Tokyo to New York, Washington, D.C. and Moscow. After a “mind-blowing” revelation, she is forced to rethink everything she once thought to be true.”

The fifth film sees the return of familiar faces and a handful of new ones, including Sienna Guillory as Jill Valentine, Johann Urb as Leon Kennedy, Boris Kodjoe as Luther West, Bingbing Li as Ada Wong, and a surprise (and very much welcome) return from Michelle Rodriguez as Rain Ocampo, who starred (and seemingly died) in 2002’s Resident Evil, the first film in the series. The franchise has grossed over $650m. to date, and I have a feeling this could tip it over the $1bn. mark.

Resident Evil: Retribution will be released in 3D and IMAX 3D on 14th September in the US, followed two weeks later on 28th September here in the UK. I’m a big fan of the films to date, and can’t help but look forward to this fifth outing. It should be immense. Here’s your new trailer to prove it, followed by a new image from the film, courtesy of Facebook.